Friday 4th November 2016

08:30-08:50 Registration

Opening by CNIC General Director (Valentín Fuster) and Conference Organizers

Session I - Mechanosensing, mechanotransduction and morphogenesis

Chair: Nadia Mercader

09:00-09:30 Mike Sheetz
Columbia University, New York. USA, Mechanobiology Institute, Singapore
Rigidity sensing contractions inhibit transformed growth

09:30-10:00 Clare Waterman
National Institutes of Health, Bethesda, USA
FMN2 makes perinuclear actin to protect nuclei during confined migration and promote metastasis

Short talk
Sandra B. Lemke
Max Planck Institute of Biochemistry, Martinsried, Germany
Measuring molecular tension at developing muscle attachment sites

Short talk
Daniela Panáková
Max Delbrück Center for Molecular Medicine, Berlin, Ger many
Planar cell polarity pathway links mechanosensitive feedback between cardiac remodelling and muscle differentiation


Coffee Break

10:50-11:20 Xavier Trepat
Institute for Bioengineering of Catalonia, Barcelona, Spain
Mechanical guidance of collective cell migration and invasion

Flash presentations

Fidel-Nicolás Lolo
Spanish National Center for Cardiovascular Research (CNIC), Madrid, Spain
Identifying mechanosensing and mechanotransducer elements within caveolae

Jose Manuel García-Aznar
Zaragoza University, Spain
The role of matrix mechanics on 3D cell migration: from microfluidics to numerical modeling

Ines Marques
Bern University, Switzerland
Role of extracellular matrix stifness in heart regeneration

César López-Pastrana
National Center of Biotechnology (CNB), CSIC, Madrid, Spain
Force and twist dependence of repc nicking activity on torsionally-constrained DNA molecules

Raúl Pérez-Jiménez
CIC nanoGUNE, San Sebastián, Spain
Mechanochemical evolution of the giant muscle protein titin as inferred from resurrected proteins



Session II - Novel experimental approaches in mechanobiology: from single molecules to in silico models

Chair: María Montoya

13:00-13:30 Jochen Guck
Technical University, Dresden, Germany
Feeling for cell function - mechanical phenotyping at 1000 cells/sec

13:30-14:00 Julio M. Fernández
Columbia University, New York. USA
How muscle works

14:00-14:30 Marino Arroyo
Polytechnic University, Barcelona. Spain
Control of epithelial resilience and shape through matrix hydraulics

14:30-15:00 Jan Lammerding
Cornell University, Ithaca, NY, USA
Nuclear mechanics during migration in 3-D environments

15:00-15:30 Vadim Frolov
University of the Basque Country, Bilbao, Spain
Mechanochemistry of membrane fission driven by dynamins

Flash presentations

Amy Beedle

King’s College London, UK
Protein s-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding

Pablo Sáez
Polytechnic University of Catalonia, Barcelona, Spain
Computational analysis of mechanical forces in the endothelial glycocalyx

Carmen Suay-Corredera
Spanish National Center for Cardiovascular Research (CNIC), Madrid, Spain
Nanomechanical phenotypes in familial hypertrophic cardiomyopathy

Roger Oria
Institute for Bioengineering of Catalonia, Barcelona, Spain
Force loading explains how substrate rigidity and ligand nano-distribution regulate cell response

16:00-16:20 Coffee Break and Poster exhibition

16:20-16:50 Roger Kamm
MIT, Cambridge, USA
The Role of Mechanical Force in Tumor Cell Migration and Extravasation

16:20-16:50 Ohad Cohen
Weizmann Institute of Science, Rehovot, Israel
Dynamical response and synchronous beating of isolated cardiaccells

Session III - Mechanical forces in the cardiovascular system

Chair: Jorge Alegre-Cebollada

16:50-17:20 Martin Schwartz
Yale University, New Haven. USA
Mechanical forces in vascular health and disease

17:20-17:50 David Warshaw
University of Vermont, Burlington, USA
Myosin Binding Protein C: Steps on the gas and brake simultaneously to regulate cardiac contractility

17:50-18:20 Julien Vermot
Institute of genetics and molecular and cellular biology, Illkirch, France
Mechanotransduction and cardiovascular morphogenesis
EMBO Young Investigator Lecture

18:20-18:50 Lucie Carrier
University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Gene therapy for pediatric sarcomeric cardiomyopathies

Short Talk
Achim Paululat.
Universität Osnabrück, Osnabrueck, Germany
Role of the ecm in modulating mechanical forces in the drosophila cardiovascular system

Short Talk
Asier Echarri
Spanish National Center for Cardiovascular Research (CNIC), Madrid, Spain
An ABL- FPB17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation

Saturday 5th November 2016

Session IV - Mechanical forces in disease

Chair: Miguel Ángel del Pozo

9:00-09:30 Valerie Weaver
University of California San Francisco, USA
Forcing tumor progression

09:30-10:00 Emmanuel Farge
Curie Institute, Paris, France
From mesoderm mechanotransductive evolutionary origins to tumourigenic mechanical induction

10:00-10:30 David Beech
University of Leeds, UK
Piezo1 channel: mechanical force sensor in the endothelium

10:30-10:50 Coffee Break and Poster exhibition

10:50-11:20 Javier Díez
University of Navarra, Pamplona, Spain
Molecular basis of mechanical alterations of the myocardial collagen network in heart failure

11:20-11:50 Elizabeth McNally
Northwestern University, Chicago, USA
Modifiers of myopathy affecting heart and muscle

Short Talk
Joe Swift
The University of Manchester, UK
Nuclear decoupling and chaperones protect cell homeostasis during mechanical loading

Short Talk
Linda J. Kenney
Mechanobiology Institute, Singapore
Super-resolution imaging of salmonella spi-2 regulation: a view from 20 nm to 30,000 fee

12:20-12:50 Stefano Piccolo
University of Padova, Italy
YAP/TAZ in somatic stem cells, organoids, tissue repair and cancer
The EMBO Keynote Lecture


Concluding remarks and farewell